Timescales of Plasticity and Underlying Mechanisms

Coordinators: József Fiser, Máté Lengyel, and Jennifer Raymond

A long-standing question in the neurobiology of learning is that of timescales. The brain can associate events that are separated by seconds, minutes, hours, days, weeks, or longer. Yet, the known biological mechanisms for inducing changes in the synaptic connections between neurons are driven by neural events that are separated by typically no more than a few tens or hundreds of milliseconds. This conference will convene scientists studying the molecular, cellular, and circuit-level mechanisms used by the brain to bridge the multiple timescales across which events play out in the experience of an individual. The goal will be to assemble an up-to-date understanding of the set of biological mechanisms available in the brain to support associative learning across different timescales. The conference's emphasis on biological mechanisms will complement and support the main program’s more computational focus, and encourage an integrated analysis of statistical learning spanning molecular, cellular, circuit, and behavioral-level phenomena.

PLEASE NOTE: During the conference there will be an opportunity to present a poster. If you are interested in presenting a poster please visit the conference website and submit your title and abstract. Each poster board is 4 feet high x 6 feet wide. We ask that the posters be no larger than 44 inches high x 34 inches wide at the most (it is important to follow these measurements or posters may be turned down due to limited space). The deadline to submit a poster is July 5.

Invited Speakers:

Cliff Abraham - Univ. of Otago

Allison Barth - CMU

Dean Buonomano - UCLA

Christine Grienberger - Brandeis

Leslie Griffith - Brandeis 

Yasunori Hayashi - Kyoto Univ.

Rich Kramer - UC Berkeley

Janine Kwapis - Penn State

Máté Lengyel - Cambridge

Mathieu Letellier - Univ. of Bordeaux

Steve Lisberger - Duke

Tom O'dell - UCLA

Azahara Oliva - Cornell

Jennifer Raymond - Stanford

Megha Sehgal - UCLA

Laurent Venance - INSERM

2023

Monday, Jul 10, 2023

  • 08:50AM Behaviorally relevant synaptic plasticity rules Fred Kavli Auditorium (Main)

    Talks are 30 min + 15 min discussion
    • 08:50AM Lars Bildsten (KITP) Welcome
    • 09:00AM Laurent Venance (INSERM) Striatum expresses region-specific plasticity consistent with distinct memory abilities
    • 09:45AM Christine Grienberger (Brandeis Univ.) Behavioral timescale plasticity in the hippocampus
  • 10:30AM MORNING BREAK Gurley Courtyard

     
  • 11:00AM Fred Kavli Auditorium (Main)

     
    • 11:00AM Jennifer Raymond (Stanford) Adaptive tuning of the timing rules for plasticity to circuit properties
    • 11:45AM Perspectives & Discussion: Behaviorally relevant synaptic plasticity rules
  • 12:30PM LUNCH BREAK Gurley Courtyard

     
  • 02:00PM Synaptic cooperativity/independence Fred Kavli Auditorium (Main)

    Talks are 30 min + 15 min discussion
    • 02:00PM Thomas O'Dell (UCLA) Behavioral Timescale Cooperativity and Competitive Synaptic Interactions
    • 02:45PM Alison Barth (CMU) Transient and layer-specific reduction in neocortical PV inhibition during sensory association learning
  • 03:30PM AFTERNOON BREAK Gurley Courtyard

     
  • 04:00PM Fred Kavli Auditorium (Main)

     
    • 04:00PM Mathieu Letellier (Univ. of Bordeaux) miR-124-dependent tagging of synapses by synaptopodin enables input-specific homeostatic plasticity
    • 04:45PM Perspectives & Discussion: Synaptic cooperativity/independence
  • 05:30PM RECEPTION Gurley Courtyard

     
  • 06:00PM SPECIAL EVENTS DINNER Gurley Courtyard

     
  • 08:00PM SHUTTLE TO BWSCI Gurley Courtyard

     

2023

Monday, Jul 10, 2023

  • 08:50AM Behaviorally relevant synaptic plasticity rules Fred Kavli Auditorium (Main)

    Talks are 30 min + 15 min discussion
    • 08:50AM Lars Bildsten (KITP) Welcome
    • 09:00AM Laurent Venance (INSERM) Striatum expresses region-specific plasticity consistent with distinct memory abilities
    • 09:45AM Christine Grienberger (Brandeis Univ.) Behavioral timescale plasticity in the hippocampus
  • 10:30AM MORNING BREAK Gurley Courtyard

     
  • 11:00AM Fred Kavli Auditorium (Main)

     
    • 11:00AM Jennifer Raymond (Stanford) Adaptive tuning of the timing rules for plasticity to circuit properties
    • 11:45AM Perspectives & Discussion: Behaviorally relevant synaptic plasticity rules
  • 12:30PM LUNCH BREAK Gurley Courtyard

     
  • 02:00PM Synaptic cooperativity/independence Fred Kavli Auditorium (Main)

    Talks are 30 min + 15 min discussion
    • 02:00PM Thomas O'Dell (UCLA) Behavioral Timescale Cooperativity and Competitive Synaptic Interactions
    • 02:45PM Alison Barth (CMU) Transient and layer-specific reduction in neocortical PV inhibition during sensory association learning
  • 03:30PM AFTERNOON BREAK Gurley Courtyard

     
  • 04:00PM Fred Kavli Auditorium (Main)

     
    • 04:00PM Mathieu Letellier (Univ. of Bordeaux) miR-124-dependent tagging of synapses by synaptopodin enables input-specific homeostatic plasticity
    • 04:45PM Perspectives & Discussion: Synaptic cooperativity/independence
  • 05:30PM RECEPTION Gurley Courtyard

     
  • 06:00PM SPECIAL EVENTS DINNER Gurley Courtyard

     
  • 08:00PM SHUTTLE TO BWSCI Gurley Courtyard

     

2023

Tuesday, Jul 11, 2023

  • 09:00AM Metaplasticity Fred Kavli Auditorium (Main)

    Talks are 30 min + 15 min discussion
    • 09:00AM Rich Kramer (UC Berkeley) Relocation of an Extrasynaptic GABAA Receptor to Inhibitory Synapses Freezes Excitatory Synaptic Strength and Preserves Memory
    • 09:45AM Cliff Abraham (Univ. of Otago) Pathway-specific TNF-mediated metaplasticity in hippocampal area CA1e
  • 10:30AM MORNING BREAK Gurley Courtyard

     
  • 11:00AM Fred Kavli Auditorium (Main)

     
    • 11:00AM Dean Buonomano (UCLA) Meta- short-term plasticity for temporal coding
    • 11:45AM Perspectives & Discussion: Metaplasticity
  • 12:30PM LUNCH BREAK Gurley Courtyard

     
  • 02:00PM SHUTTLE TO BWSCI Gurley Courtyard

    FREE AFTERNOON

2023

Wednesday, Jul 12, 2023

  • 09:00AM Systems Consolidation Fred Kavli Auditorium (Main)

    Talks are 30 min + 15 min discussion
    • 09:00AM Leslie Griffith (Brandeis Univ.) Role of sleep in memory consolidation
    • 09:45AM Steve Lisberger (Duke) Principles of operation of a cerebellar learning circuit
  • 10:30AM MORNING BREAK Gurley Courtyard

     
  • 11:00AM Fred Kavli Auditorium (Main)

     
    • 11:00AM Yasunori Hayashi (Kyoto Univ.) Stepwise synaptic plasticity events drive the early phase of memory consolidation
    • 11:45AM Azahara Oliva (Cornell) Long-duration Hippocampal Sharp Wave Ripples Improve Memory
  • 12:30PM LUNCH BREAK Gurley Courtyard

     
  • 02:00PM Discussion & Poster Session Fred Kavli Auditorium (Main)

    Talks are 30 min + 15 min discussion
    • 02:00PM Perspectives & Discussion: Systems consolidation
    • 02:45PM Poster session
  • 03:30PM AFTERNOON BREAK Gurley Courtyard

     
  • 04:00PM Discussion & Poster Session Fred Kavli Auditorium (Main)

     
    • 04:00PM Poster session
  • 05:30PM RECEPTION Gurley Courtyard

     
  • 06:00PM SPECIAL EVENTS DINNER Gurley Courtyard

     
  • 08:00PM SHUTTLE TO BWSCI Gurley Courtyard

     

2023

Thursday, Jul 13, 2023

  • 09:00AM Memory updating Fred Kavli Auditorium (Main)

    Talks are 30 min + 15 min discussion
    • 09:00AM Megha Seghal (UCLA) Memory linking
    • 09:45AM Máté Lengyel (Cambridge) Contextual inference underlies the learning of sensorimotor repertoires
  • 10:30AM MORNING BREAK Gurley Courtyard

     
  • 11:00AM Fred Kavli Auditorium (Main)

     
    • 11:00AM Janine Kwapis (Penn State) Molecular Mechanisms of Reconsolidation-Dependent Memory Updating
    • 11:45AM Perspectives and Discussion: Memory updating
  • 12:30PM LUNCH Gurley Courtyard

     
  • 02:00PM CONFERENCE END SHUTTLE TO BWSCI *Also available to SB Airport and SB Airbus, Goleta location (See Registration Desk BEFORE THURSDAY to sign up.) Gurley Courtyard

     

2023

Friday, Jul 14, 2023

No talks scheduled.

2023

Saturday, Jul 15, 2023

No talks scheduled.

2023

Sunday, Jul 16, 2023

No talks scheduled.