String theory encompasses a wide range of perspectives on the nature of spacetime, from qubit models of black hole information to the string worldsheet. This conference will aim for a new synthesis of the field that builds on recent progress on the role of quantum information, new top-down techniques in string compactification and string field theory, and growing evidence for precise holographic dualities beyond anti-de Sitter space. The focus will be on bridging the divide between the IR and the UV. We will explore recent progress in non-perturbative string theory and stringy constraints on effective field theory, and develop the connections between the gravitational path integral, higher topologies, and entanglement, from low energy to the string scale.