Over the past few years, much progress has been made in elucidating the impact of non-equilibrium dynamics on a wide range of systems studied in physics and biology, from active materials to evolutionary landscapes and ecosystems. To account for and unify the increasing corpus of experimental results obtained in these fields, new theoretical tools have been developed, ranging from random-matrix and large-deviation theories to coarse-graining and high-dimensional optimization methods. The goal of this conference is to gather experimentalists and theoreticians who have contributed to these developments and to identify the new research directions that can emerge from their diversity of skills and interest.